Micky van de Ven Brace Ends The Toffees' Run at Brand New Stadium
Micky van de Ven emerged as the first defender to score two goals in a English top-flight game for Spurs since Jan Vertonghen in March 2013.
Match summary
The Spurs defender heads home twice in first half
Everton's defender has equalizer ruled after video check
Senegalese midfielder scores third in dying moments
The defeat is the Merseyside club's first at their new ground
Micky van de Ven found the net on two occasions as Tottenham prolonged their winning streak in away games in the Premier League and handed Everton their initial loss at their new home.
Everton were unbeaten in their last five matches at their recently opened stadium at the dockside location, having left their historic home behind after 133 years at the conclusion of last season.
But Tottenham's leader Van de Ven struck twice from set-pieces in the opening 45 minutes to put their impressive record at jeopardy, and they were failed to mount a comeback before the midfielder - set up by former Toffees attacker the Brazilian - headed home a final goal to put the game to bed.
Jake O'Brien thought he had equalized the scores five minutes after Van de Ven's opener, glancing a bullet header past Guglielmo Vicario from an set-piece.
The Portuguese striker, in the meantime, failed to convert a number of opportunities, while Vicario made a series of fine saves to guarantee the London club went five matches on the road unbeaten in the English top flight.
But the VAR stepped in, instructing Craig Pawson to review the score on the screen and the official ruled that Jack Grealish and Iliman Ndiaye were in an illegal position and had interfered with the Tottenham goalkeeper.
This victory elevates Thomas Frank's side into third place in the division, five points off local foes and table-toppers the Gunners.
The Merseyside club remain in 14th position and are six points ahead of the relegation zone.
Tottenham analysis: The defender excels in duties at both ends of the field
After a uninspiring midweek display in the European competition against Monaco, where they managed a only attempts on goal, Frank opted for the French striker up front instead of ex-Everton forward the Brazilian.
The new arrival was failed to influence the game before being substituted for Richarlison after 60 minutes on the field, but it turns out he proved unnecessary in the end.
Defender the Dutchman transformed into an attacking force to be feared.
Tottenham's opening strike came from a well-worked set-piece play, with Rodrigo Bentancur directing the ball toward the six-yard box for an free the defender to head home.
And Ven de Ven - stepping up as skipper in the Argentine's unavailability - notched his next goal in added time as he outjumped Jordan Pickford to nod in.
Van de Ven was just as impressive in defensive duties, partnering effectively with his defensive colleague as the duo handled excellently with the numerous deliveries thrown their way by the opposition.
Toffees breakdown: Everton missing finishing touch
The club's recent stadium had been a happy hunting ground, but it appears the novelty may have faded somewhat and supporters flocked to the exits after the midfielder's third for Tottenham.
The end in the team's winning streak at home will not be a massive concern for David Moyes, but their striker situation will be.
The forward and the other striker - the Everton's pair of established centre-forwards - had scored only a single goal between them before the weekend's outing.
And they were unable to contribute to that miserable record on a damp and dreary evening on in Liverpool.
Beto's performance was summed up when he chose to bicycle-kick a golden opportunity from close range, even with having space and time to reposition for a simpler attempt that would have tested the keeper.
Barry, too, failed to influence the game after coming on for the starter in the 65th minute.
It wasn't for a lack of chance. The majority of the home side's attacks came through Grealish and Ndiaye, who tirelessly delivered threatening crosses into the Tottenham box.
What next for both teams?
Everton: Moyes' men head to the Stadium of Light in the top flight on early November at 20:00 GMT.
Spurs: The London club travel to Newcastle's ground on Wednesday, 29 October for their next round Carabao Cup tie against Newcastle.